Issue 17, 2016
From the journal:

Chemical Communications

A fluorescent switchable AIE probe for selective imaging of dipeptidyl peptidase-4 in vitro and in vivo and its application in screening DPP-4 inhibitors†

Yi Wang,*ab   Xueli Wu,c   Yiyu Chengab  and  Xiaoping Zhao*c  

* Corresponding authors

a College of Pharmaceutical Sciences, Zhejiang University (Zijingang Campus), Hangzhou, P. R. China
E-mail: mysky@zju.edu.cn

b Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Zhejiang University, Hangzhou, P. R. China

c College of Preclinical Medicine, Zhejiang Chinese Medical University, Hangzhou, P. R. China
E-mail: zhaoxiaoping@zcmu.edu.cn

Abstract

A novel fluorescent probe for in vitro and in vivo imaging of dipeptidyl peptidase-4 (DPP-4) was designed and synthesized. This probe is successfully utilized to screen DPP-4 inhibitors in living 3T3-L1 cells and zebrafish, which provides a novel approach for the discovery of anti-diabetes drugs.

Graphical abstract: A fluorescent switchable AIE probe for selective imaging of dipeptidyl peptidase-4 in vitro and in vivo and its application in screening DPP-4 inhibitors

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Article information

DOI
https://doi.org/10.1039/C5CC08921B
Article type
Communication
Submitted
27 Oct 2015
Accepted
19 Jan 2016
First published
19 Jan 2016

Chem. Commun., 2016,52, 3478-3481

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A fluorescent switchable AIE probe for selective imaging of dipeptidyl peptidase-4 in vitro and in vivo and its application in screening DPP-4 inhibitors

Y. Wang, X. Wu, Y. Cheng and X. Zhao, Chem. Commun., 2016, 52, 3478 DOI: 10.1039/C5CC08921B

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