Fully synthetic self-adjuvanting MUC1-fibroblast stimulating lipopeptide 1 conjugates as potential cancer vaccines

Yonghui Liu; Wenpeng Zhang; Qianqian He; Fan Yu; Tianbang Song; Tingting Liu; Zhenqing Zhang; Jun Zhou; Peng George Wang; Wei Zhao

doi:10.1039/C6CC04623A

Fully synthetic self-adjuvanting MUC1-fibroblast stimulating lipopeptide 1 conjugates as potential cancer vaccines†

Yonghui Liu,‡^a Wenpeng Zhang,‡^b Qianqian He,^c Fan Yu,^c Tianbang Song,^a Tingting Liu,^a Zhenqing Zhang,^b Jun Zhou,^c Peng George Wang*^a and Wei Zhao*^a

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* Corresponding authors

^a State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Haihe Education Park, 38 Tongyan Road, Tianjin 300353, P. R. China
E-mail: wzhao@nankai.edu.cn, pwang@nankai.edu.cn
Fax: +86 22-23507760
Tel: +86 22-23507760

^b State Key Laboratory of Toxicology and Medical Countermeasures, Beijing Institute of Pharmacology and Toxicology, Beijing 100850, P. R. China

^c College of Life Sciences, Nankai University, Tianjin 300071, P. R. China

Abstract

We have designed and synthesized MUC1-fibroblast stimulating lipopeptide 1 conjugates as potential self-adjuvanting cancer vaccines using a linear solid phase peptide synthesis strategy. These vaccine candidates have elicited T cell dependent immune response and the induced antibodies showed intense specific binding affinity to human MCF-7 cells.

Chemical Communications

Fully synthetic self-adjuvanting MUC1-fibroblast stimulating lipopeptide 1 conjugates as potential cancer vaccines†

Abstract

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Fully synthetic self-adjuvanting MUC1-fibroblast stimulating lipopeptide 1 conjugates as potential cancer vaccines

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