Issue 12, 2016
From the journal:

Organic & Biomolecular Chemistry

Modifying the phenyl group of PUGNAc: reactivity tuning to deliver selective inhibitors for N-acetyl-d-glucosaminidases†‡

Mitchell Hattie,a   Nevena Cekic,b   Aleksandra W. Debowski,ac   David J. Vocadlobd  and  Keith A. Stubbs*a  

* Corresponding authors

a School of Chemistry and Biochemistry, The University of Western Australia, Crawley, WA 6009, Australia
E-mail: keith.stubbs@uwa.edu.au

b Department of Chemistry, Simon Fraser University, Burnaby, British Columbia, Canada

c School of Pathology and Laboratory Medicine, The University of Western Australia, Crawley, WA 6009, Australia

d Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, British Columbia, Canada

Abstract

The synthesis of analogues of the potent N-acetylhexosaminidase inhibitor, PUGNAc, are described. These compounds were assayed against a set of biologically important N-acetyl-D-glucosaminidases and were found to vary in both potency and selectivity.

Graphical abstract: Modifying the phenyl group of PUGNAc: reactivity tuning to deliver selective inhibitors for N-acetyl-d-glucosaminidases

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Article information

DOI
https://doi.org/10.1039/C6OB00297H
Article type
Communication
Submitted
05 Feb 2016
Accepted
23 Feb 2016
First published
23 Feb 2016

Org. Biomol. Chem., 2016,14, 3193-3197

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Modifying the phenyl group of PUGNAc: reactivity tuning to deliver selective inhibitors for N-acetyl-D-glucosaminidases

M. Hattie, N. Cekic, A. W. Debowski, D. J. Vocadlo and K. A. Stubbs, Org. Biomol. Chem., 2016, 14, 3193 DOI: 10.1039/C6OB00297H

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