Issue 31, 2016
From the journal:

Organic & Biomolecular Chemistry

Brønsted acid cocatalysis in photocatalytic intramolecular coupling of tertiary amines: efficient synthesis of 2-arylindols†

Xiaoqian Yuan,a   Xinxin Wu,a   Shupeng Dong,a   Guibing Wua  and  Jinxing Ye*a  

* Corresponding authors

a Engineering Research Centre of Pharmaceutical Process Chemistry, Ministry of Education; Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, 130 Meilong Load, Shanghai 200237, China
E-mail: yejx@ecust.edu.cn

Abstract

We report herein a highly efficient intramolecular coupling reaction of tertiary amines and ketones (α,β-unsaturated ketones) by using a Brønsted acid as a cocatalyst, affording 2-arylindols in good to excellent yields (up to 92%) under visible light irradiation at room temperature.

Graphical abstract: Brønsted acid cocatalysis in photocatalytic intramolecular coupling of tertiary amines: efficient synthesis of 2-arylindols

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Article information

DOI
https://doi.org/10.1039/C6OB01239F
Article type
Communication
Submitted
07 Jun 2016
Accepted
11 Jul 2016
First published
11 Jul 2016

Org. Biomol. Chem., 2016,14, 7447-7450

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Brønsted acid cocatalysis in photocatalytic intramolecular coupling of tertiary amines: efficient synthesis of 2-arylindols

X. Yuan, X. Wu, S. Dong, G. Wu and J. Ye, Org. Biomol. Chem., 2016, 14, 7447 DOI: 10.1039/C6OB01239F

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