Issue 2, 2016

A benzo[c]carbazolyl-based phosphine ligand for Pd-catalyzed tetra-ortho-substituted biaryl syntheses

Abstract

A new benzo[c]carbazolyl-based phosphine ligand has been designed and synthesized. This newly developed ligand efficiently facilitates the Pd-catalyzed tetra-ortho-substituted biaryl syntheses via Suzuki–Miyaura cross-coupling. With 1 mol% of the Pd(OAc)2/L6 catalyst, sterically congested biaryls were afforded in good-to-excellent yields. In particular, the mild reaction conditions exhibited good compatibility of heterocycles and functional groups including esters and nitrile. L6 was structurally characterized by X-ray crystallographic analysis.

Graphical abstract: A benzo[c]carbazolyl-based phosphine ligand for Pd-catalyzed tetra-ortho-substituted biaryl syntheses

Supplementary files

Article information

Article type
Research Article
Submitted
25 Nov 2015
Accepted
26 Dec 2015
First published
28 Dec 2015

Org. Chem. Front., 2016,3, 273-276

Author version available

A benzo[c]carbazolyl-based phosphine ligand for Pd-catalyzed tetra-ortho-substituted biaryl syntheses

W. C. Fu, Z. Zhou and F. Y. Kwong, Org. Chem. Front., 2016, 3, 273 DOI: 10.1039/C5QO00400D

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