A 7-methoxytacrine–4-pyridinealdoxime hybrid as a novel prophylactic agent with reactivation properties in organophosphate intoxication

E. Nepovimova; J. Korabecny; R. Dolezal; T. D. Nguyen; D. Jun; O. Soukup; M. Pasdiorova; P. Jost; L. Muckova; D. Malinak; L. Gorecki; K. Musilek; Kamil Kuca

doi:10.1039/C6TX00130K

A 7-methoxytacrine–4-pyridinealdoxime hybrid as a novel prophylactic agent with reactivation properties in organophosphate intoxication†

E. Nepovimova,^a J. Korabecny,^a R. Dolezal,^a T. D. Nguyen,^a D. Jun,^ab O. Soukup,^a M. Pasdiorova,^a P. Jost,^a L. Muckova,^b D. Malinak,^a L. Gorecki,^a K. Musilek^a and Kamil Kuca*^a

Author affiliations

* Corresponding authors

^a Biomedical Research Centre, University Hospital Hradec Kralove, Sokolska 581, 500 05 Hradec Kralove, Czech Republic
E-mail: kamil.kuca@fnhk.cz

^b Department of Toxicology and Military Pharmacy, Faculty of Military Health Sciences, University of Defence, Trebesska 1575, 500 01 Hradec Kralove, Czech Republic

Abstract

Chemical warfare agents constitute an increasing threat to both military and civilian populations. Therefore, effective prophylactic approaches are urgently needed. Herein, we present a novel hybrid compound which is able not only to keep acetylcholinesterase resistant to organophosphate (OP) inhibitors, but also to serve as an enzyme reactivator in the case of OP intoxication.

Toxicology Research

A 7-methoxytacrine–4-pyridinealdoxime hybrid as a novel prophylactic agent with reactivation properties in organophosphate intoxication†

Abstract

Supplementary files

Article information

Download Citation

Search articles by author

Spotlight

Advertisements