Issue 82, 2017
From the journal:

Chemical Communications

Alanine scan reveals modifiable residues in teixobactin†

K. H. Chen, ORCID logo a   S. P. Le,a   X. Han,a   J. M. Friasa  and  J. S. Nowick ORCID logo *a  

* Corresponding authors

a Department of Chemistry, University of California, Irvine, Irvine, California, USA
E-mail: jsnowick@uci.edu

Abstract

An alanine scan of Lys10-teixobactin reveals that a cationic residue at position 10 is not necessary for antibiotic activity and that position 3 tolerates substitution without loss of activity. An unexpected correlation between poor aqueous solubility and better antibiotic activity of the teixobactin analogues is observed.

Graphical abstract: Alanine scan reveals modifiable residues in teixobactin

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Article information

DOI
https://doi.org/10.1039/C7CC03415F
Article type
Communication
Submitted
03 May 2017
Accepted
22 Sep 2017
First published
25 Sep 2017

Chem. Commun., 2017,53, 11357-11359

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Alanine scan reveals modifiable residues in teixobactin

K. H. Chen, S. P. Le, X. Han, J. M. Frias and J. S. Nowick, Chem. Commun., 2017, 53, 11357 DOI: 10.1039/C7CC03415F

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