Issue 78, 2017
From the journal:

Chemical Communications

Ruthenium-catalysed one-pot regio- and diastereoselective synthesis of pyrrolo[1,2-a]indoles via cascade C–H functionalization/annulation†

Sukhdev Singh, ORCID logo ‡a   Himanshu H. Butani,‡ab   Dipak D. Vachhani,*b   Anamik Shahb  and  Erik V. Van der Eycken ORCID logo *ac  

* Corresponding authors

a Laboratory for Organic & Microwave-Assisted Chemistry (LOMAC), Department of Chemistry, University of Leuven (KU Leuven), Celestijnenlaan 200F, Leuven, Belgium
E-mail: erik.vandereycken@chem.kuleuven.be, ddvachhani@gmail.com

b Department of Chemistry, Saurashtra University, Rajkot, India

c Peoples Friendship University of Russia (RUDN University) Miklukho-Maklaya street 6, 117198 Moscow, Russia

Abstract

A cascade approach has been developed towards dual C–C bond formation via consecutive C–H functionalization/cyclization giving access to pyrrolo[1,2-a]indoles in a highly regio- and diastereoselective manner using catalytic [Ru(p-cymene)Cl2]2. The methodology was further expanded to attain pentacyclic structures involving manifold C–C bond creation.

Graphical abstract: Ruthenium-catalysed one-pot regio- and diastereoselective synthesis of pyrrolo[1,2-a]indoles via cascade C–H functionalization/annulation

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Article information

DOI
https://doi.org/10.1039/C7CC06276A
Article type
Communication
Submitted
10 Aug 2017
Accepted
08 Sep 2017
First published
11 Sep 2017

Chem. Commun., 2017,53, 10812-10815

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Ruthenium-catalysed one-pot regio- and diastereoselective synthesis of pyrrolo[1,2-a]indoles via cascade C–H functionalization/annulation

S. Singh, H. H. Butani, D. D. Vachhani, A. Shah and E. V. Van der Eycken, Chem. Commun., 2017, 53, 10812 DOI: 10.1039/C7CC06276A

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