Issue 15, 2017
From the journal:

Organic & Biomolecular Chemistry

A tunable copper-catalyzed multicomponent reaction towards alkaloid-inspired indole/lactam polycycles†

M. I. D. Mardjan,a   S. Perie,a   J.-L. Parrain*a  and  L. Commeiras ORCID logo *a  

* Corresponding authors

a Aix Marseille Univ, CNRS, Centrale Marseille, iSm2, Marseille, France
E-mail: laurent.commeiras@univ-amu.fr, jl.parrain@univ-amu.fr
Fax: (+33)-(0)491-288-86
Tel: (+33)-(0)491-289-126

Abstract

A versatile copper(I)-catalyzed cascade multicomponent reaction strategy between readily available (Z)-3-iodoacrylic acids, terminal alkynes, and primary amines is reported, leading to a great diversity of complex heterocyclic backbones based on biorelevant indole/lactam scaffolds.

Graphical abstract: A tunable copper-catalyzed multicomponent reaction towards alkaloid-inspired indole/lactam polycycles

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Article information

DOI
https://doi.org/10.1039/C7OB00532F
Article type
Paper
Submitted
02 Mar 2017
Accepted
17 Mar 2017
First published
17 Mar 2017

Org. Biomol. Chem., 2017,15, 3304-3309

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A tunable copper-catalyzed multicomponent reaction towards alkaloid-inspired indole/lactam polycycles

M. I. D. Mardjan, S. Perie, J.-L. Parrain and L. Commeiras, Org. Biomol. Chem., 2017, 15, 3304 DOI: 10.1039/C7OB00532F

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