Issue 23, 2017

Metal-free regioselective formation of C–N and C–O bonds with the utilization of diaryliodonium salts in water: facile synthesis of N-arylquinolones and aryloxyquinolines

Abstract

Regioselective construction of crucial C–N and C–O bonds leading to N-arylquinolones and aryloxyquinolines has been accomplished by employing easily accessible diaryliodonium salts and quinolones in water under metal- and ligand-free conditions. This operationally simple strategy is significant due to mild reaction conditions, high product yields, recyclability of released iodoarenes and scalability to the gram level. The practical utility of the developed protocol was proved by the arylation of medicinally important heterocycles like acridin-9(10H)-one, 3-methylquinoxalin-2(1H)-one and 1H-benzo[d]imidazol-2(3H)-one.

Graphical abstract: Metal-free regioselective formation of C–N and C–O bonds with the utilization of diaryliodonium salts in water: facile synthesis of N-arylquinolones and aryloxyquinolines

Supplementary files

Article information

Article type
Communication
Submitted
17 Apr 2017
Accepted
16 May 2017
First published
16 May 2017

Org. Biomol. Chem., 2017,15, 4956-4961

Metal-free regioselective formation of C–N and C–O bonds with the utilization of diaryliodonium salts in water: facile synthesis of N-arylquinolones and aryloxyquinolines

M. K. Mehra, M. P. Tantak, V. Arun, I. Kumar and D. Kumar, Org. Biomol. Chem., 2017, 15, 4956 DOI: 10.1039/C7OB00940B

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