Efficient synthesis of multiply substituted butenolides from keto acids and terminal alkynes promoted by combined acids

Wenbin Mao; Chen Zhu

doi:10.1039/C6QO00820H

You do not have JavaScript enabled. Please enable JavaScript to access the full features of the site or access our non-JavaScript page.

Efficient synthesis of multiply substituted butenolides from keto acids and terminal alkynes promoted by combined acids†

Wenbin Mao^a and Chen Zhu

*^ab

Author affiliations

* Corresponding authors

^a Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, 199 Ren-Ai Road, Suzhou, Jiangsu 215123, China
E-mail: chzhu@suda.edu.cn

^b Key Laboratory of Synthetic Chemistry of Natural Substances, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, China

Abstract

A general, efficient, and operationally simple approach to highly substituted butenolides through the annulation of keto acids and terminal alkynes is described. This reaction is promoted by the combination of Lewis and Brønsted acids, furnishing a variety of butenolides in synthetically useful yields.

Download options Please wait...

Supplementary files

Article information

DOI: https://doi.org/10.1039/C6QO00820H
Article type: Research Article
Submitted: 16 Dec 2016
Accepted: 13 Feb 2017
First published: 14 Feb 2017

Download Citation

Org. Chem. Front., 2017,4, 1029-1033

Permissions

Request permissions

Efficient synthesis of multiply substituted butenolides from keto acids and terminal alkynes promoted by combined acids

W. Mao and C. Zhu, Org. Chem. Front., 2017, 4, 1029 DOI: 10.1039/C6QO00820H

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Social activity

Fetching data from CrossRef.
This may take some time to load.

Organic Chemistry Frontiers

Efficient synthesis of multiply substituted butenolides from keto acids and terminal alkynes promoted by combined acids†

Abstract

Supplementary files

Article information

Download Citation

Permissions

Efficient synthesis of multiply substituted butenolides from keto acids and terminal alkynes promoted by combined acids

Social activity

Search articles by author

Spotlight

Advertisements