Issue 15, 2018
From the journal:

Chemical Communications

N terminal N-methylation modulates chiral centre induced helical (CIH) peptides’ biophysical properties†

Wenjun Li,‡a   Kuan Hu, ORCID logo ‡bc   Qingzhou Zhang,a   Dongyuan Wang,a   Yue Ma,a   Zhanfeng Hou,a   Feng Yin ORCID logo *a  and  Zigang Li ORCID logo *a  

* Corresponding authors

a The Key Laboratory of Chemical Genomics School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen, China
E-mail: yinfeng@pkusz.edu.cn, lizg@pkusz.edu.cn

b Beijing Institute of Nanoenergy and Nanosystems, National Center for Nanoscience and Technology (NCNST), Chinese Academy of Sciences, Beijing 100083, China

c College of Nanoscience and Technology, University of Chinese Academy of Sciences, Beijing 100049, P. R. China

Abstract

The effects of N-methylation on CIH peptides’ biophysical properties were systematically studied. N-Methylation at the N terminal NH could help improve the peptides’ cellular uptake with a retained helical conformation. This N-methylation strategy could also be applied to longer peptides to improve their stability and cellular uptake.

Graphical abstract: N terminal N-methylation modulates chiral centre induced helical (CIH) peptides’ biophysical properties

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Article information

DOI
https://doi.org/10.1039/C7CC09201F
Article type
Communication
Submitted
30 Nov 2017
Accepted
23 Jan 2018
First published
23 Jan 2018

Chem. Commun., 2018,54, 1865-1868

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N terminal N-methylation modulates chiral centre induced helical (CIH) peptides’ biophysical properties

W. Li, K. Hu, Q. Zhang, D. Wang, Y. Ma, Z. Hou, F. Yin and Z. Li, Chem. Commun., 2018, 54, 1865 DOI: 10.1039/C7CC09201F

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