Issue 10, 2018

Synthesis of indolizine derivatives containing eight-membered rings via a gold-catalyzed two-fold hydroarylation of diynes

Abstract

A gold-catalyzed method for the construction of indolizines with eight-membered rings has been developed. The reaction proceeded through a two-fold hydroarylation with indole or pyrrole derivatives containing a 1,6-diyne using a tri(1-adamantyl)phosphine gold complex as the catalyst, affording 1,8-disubstituted indolizines in moderate to good yields in DCE at 80 °C. The potential usefulness of these indolizines as blue or green OLEDs has been also disclosed.

Graphical abstract: Synthesis of indolizine derivatives containing eight-membered rings via a gold-catalyzed two-fold hydroarylation of diynes

Supplementary files

Article information

Article type
Communication
Submitted
02 Dec 2017
Accepted
06 Jan 2018
First published
08 Jan 2018

Chem. Commun., 2018,54, 1225-1228

Synthesis of indolizine derivatives containing eight-membered rings via a gold-catalyzed two-fold hydroarylation of diynes

R. Liu, Q. Wang, Y. Wei and M. Shi, Chem. Commun., 2018, 54, 1225 DOI: 10.1039/C7CC09250D

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