Issue 36, 2018

Heparin-induced tau filaments are structurally heterogeneous and differ from Alzheimer's disease filaments

Abstract

Alzheimer's disease (AD) is characterized by the presence of tau filaments in the brain whose structure was recently solved. The formation of AD filaments is routinely modeled in vitro by mixing tau with heparin. This study shows that heparin-induced tau filaments are markedly different from the AD filaments and are highly heterogeneous.

Graphical abstract: Heparin-induced tau filaments are structurally heterogeneous and differ from Alzheimer's disease filaments

Associated articles

Supplementary files

Article information

Article type
Communication
Submitted
16 Feb 2018
Accepted
05 Apr 2018
First published
11 Apr 2018

Chem. Commun., 2018,54, 4573-4576

Heparin-induced tau filaments are structurally heterogeneous and differ from Alzheimer's disease filaments

Y. Fichou, M. Vigers, A. K. Goring, N. A. Eschmann and S. Han, Chem. Commun., 2018, 54, 4573 DOI: 10.1039/C8CC01355A

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