Issue 36, 2018

Metabolite amyloid-like fibrils interact with model membranes

Abstract

Amyloid-like structure formation by various metabolites represents a significant extension of the amyloidogenic building block family. Similar to protein amyloids, metabolite amyloids induce apoptotic toxicity, a process that was linked to membrane association. Here, we demonstrate that metabolite amyloids interact with model membranes and study the mechanism by molecular dynamics.

Graphical abstract: Metabolite amyloid-like fibrils interact with model membranes

Supplementary files

Article information

Article type
Communication
Submitted
19 Feb 2018
Accepted
10 Apr 2018
First published
17 Apr 2018

Chem. Commun., 2018,54, 4561-4564

Author version available

Metabolite amyloid-like fibrils interact with model membranes

S. Shaham-Niv, P. Rehak, D. Zaguri, S. Kolusheva, P. Král and E. Gazit, Chem. Commun., 2018, 54, 4561 DOI: 10.1039/C8CC01423J

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