Issue 55, 2018

Aggregation kinetics of the Aβ1–40 peptide monitored by NMR

Abstract

The aggregation of Aβ1–40 was monitored by solution NMR, which showed a trend complementary to the one observed by ThT-fluorescence. The NMR data support a kinetic model where Aβ1–40 initially aggregates with the reversible formation of oligomeric species, which then irreversibly convert into fibrils.

Graphical abstract: Aggregation kinetics of the Aβ1–40 peptide monitored by NMR

Supplementary files

Article information

Article type
Communication
Submitted
20 Mar 2018
Accepted
03 May 2018
First published
16 May 2018

Chem. Commun., 2018,54, 7601-7604

Aggregation kinetics of the Aβ1–40 peptide monitored by NMR

G. Bellomo, S. Bologna, L. Gonnelli, E. Ravera, M. Fragai, M. Lelli and C. Luchinat, Chem. Commun., 2018, 54, 7601 DOI: 10.1039/C8CC01710G

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