Issue 59, 2018
From the journal:

Chemical Communications

A new strategy for hydrophobic drug delivery using a hydrophilic polymer equipped with stacking units†

Peng-Fei Cui,‡abcd   Wan-Ru Zhuang,‡a   Xi Hu, ORCID logo ‡e   Lei Xing,abcd   Ru-Yi Yu,a   Jian-Bin Qiao,a   Yu-Jing He,a   Fangyuan Li,e   Daishun Ling ORCID logo *e  and  Hu-Lin Jiang ORCID logo *abcd  

* Corresponding authors

a State Key Laboratory of Natural Medicines, Department of Pharmaceutics, China Pharmaceutical University, Nanjing 210009, China
E-mail: jianghulin3@163.com

b Jiangsu Key Laboratory of Drug Screening, China Pharmaceutical University, Nanjing 210009, China

c Jiangsu Key Laboratory of Drug Discovery for Metabolic Diseases, China Pharmaceutical University, Nanjing 210009, China

d Jiangsu Key Laboratory of Drugaability of Biopharmaceuticals, China Pharmaceutical University, Nanjing, China

e State Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China
E-mail: lingds@zju.edu.cn

Abstract

A highly hydrophilic polymer equipped with guanidinium groups was used to load aromatic ring-containing hydrophobic agent doxorubicin (DOX) via π–π interaction. The results have shown that the delivery system exhibited enhanced cellular uptake and antitumor efficiency compared with free drugs. This study opens new avenues for the application of hydrophilic polymers in drug delivery.

Graphical abstract: A new strategy for hydrophobic drug delivery using a hydrophilic polymer equipped with stacking units

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Article information

DOI
https://doi.org/10.1039/C8CC04363A
Article type
Communication
Submitted
01 Jun 2018
Accepted
29 Jun 2018
First published
04 Jul 2018

Chem. Commun., 2018,54, 8218-8221

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A new strategy for hydrophobic drug delivery using a hydrophilic polymer equipped with stacking units

P. Cui, W. Zhuang, X. Hu, L. Xing, R. Yu, J. Qiao, Y. He, F. Li, D. Ling and H. Jiang, Chem. Commun., 2018, 54, 8218 DOI: 10.1039/C8CC04363A

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