Fe-Catalyzed tandem cyclization for the synthesis of 3-nitrofurans from homopropargylic alcohols and Al(NO3)3·9H2O

Ting Wang; Yong Jiang; Yanyan Wang; Rulong Yan

doi:10.1039/C8OB01184B

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Fe-Catalyzed tandem cyclization for the synthesis of 3-nitrofurans from homopropargylic alcohols and Al(NO₃)₃·9H₂O†

Ting Wang,

^a Yong Jiang,

^b Yanyan Wang

^c and Rulong Yan

*^a

Author affiliations

* Corresponding authors

^a State Key Laboratory of Applied Organic Chemistry, Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province, Department of Chemistry, Lanzhou University, Lanzhou, Gansu, China
E-mail: yanrl@lzu.edu.cn
Fax: +931-8912596

^b School of Chemistry and Chemical Engineering, Yangtze Normal University, Chongqing, China

^c Jinchuan Advanced Materials Technology Co., Ltd., Lanzhou, Gansu, China

Abstract

Al(NO₃)₃·9H₂O as a nitro source for the synthesis of 3-nitrofurans from homopropargylic alcohols through Fe-catalyzed tandem cyclization is described. In this transformation, the substituted nitrofurans are obtained through nitration and cyclization. The substrate homopropargylic alcohols with different groups participate smoothly in this process and the desired substituted nitrofurans were obtained in moderate yields.

This article is part of the themed collection: Synthetic methodology in OBC

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Article information

DOI: https://doi.org/10.1039/C8OB01184B
Article type: Communication
Submitted: 20 May 2018
Accepted: 29 Jun 2018
First published: 02 Jul 2018

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Org. Biomol. Chem., 2018,16, 5232-5235

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Fe-Catalyzed tandem cyclization for the synthesis of 3-nitrofurans from homopropargylic alcohols and Al(NO₃)₃·9H₂O

T. Wang, Y. Jiang, Y. Wang and R. Yan, Org. Biomol. Chem., 2018, 16, 5232 DOI: 10.1039/C8OB01184B

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Organic & Biomolecular Chemistry