Issue 35, 2019

Monitoring autophagy in live cells with a fluorescent light-up probe for G-quadruplex structures

Abstract

Monitoring autophagy can provide valuable insights into understanding human pathological mechanisms, developing novel drugs, and exploring autophagy control approaches. Here, we proposed a new strategy to specifically monitor autophagy by lighting up the G-quadruplex structures entering autolysosomes. Based on this strategy, we designed a small-molecule fluorescent probe for autophagy imaging. This work not only opens up a new way for developing autophagy probes, but also provides an effective tool for autophagy research.

Graphical abstract: Monitoring autophagy in live cells with a fluorescent light-up probe for G-quadruplex structures

Supplementary files

Article information

Article type
Communication
Submitted
13 Feb 2019
Accepted
19 Mar 2019
First published
19 Mar 2019

Chem. Commun., 2019,55, 5060-5063

Monitoring autophagy in live cells with a fluorescent light-up probe for G-quadruplex structures

H. Chen, H. Sun, S. Zhang, W. Yan, Q. Li, A. Guan, J. Xiang, M. Liu and Y. Tang, Chem. Commun., 2019, 55, 5060 DOI: 10.1039/C9CC01263J

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