Issue 31, 2019
From the journal:

Chemical Communications

Head to tail cyclisation of cell-penetrating peptides: impact on GAG-dependent internalisation and direct translocation†

Mehdi Amoura,a   Françoise Illien, ORCID logo a   Alain Joliot,b   Karine Guitot,a   John Offer, ORCID logo c   Sandrine Sagan ORCID logo a  and  Fabienne Burlina ORCID logo *a  

* Corresponding authors

a Sorbonne Université, École normale supérieure, PSL University, CNRS, Laboratoire des Biomolécules, LBM, 75005 Paris, France
E-mail: fabienne.burlina@sorbonne-universite.fr

b Center for Interdisciplinary Research in Biology (CIRB), Collège de France, CNRS, INSERM, PSL Research University, Paris, France

c The Francis Crick Institute, 1 Midland Road, London, UK

Abstract

A series of cyclic lipidated oligo-Arg cell penetrating peptides were synthesised with varied macrocycle size and lipid chain anchoring site. The study of their cellular uptake revealed different structural requirements to promote efficient glycosaminoglycan-dependent endocytosis and direct translocation.

Graphical abstract: Head to tail cyclisation of cell-penetrating peptides: impact on GAG-dependent internalisation and direct translocation

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C9CC01265F
Article type
Communication
Submitted
13 Feb 2019
Accepted
27 Mar 2019
First published
01 Apr 2019

Chem. Commun., 2019,55, 4566-4569

Permissions

Request permissions

Head to tail cyclisation of cell-penetrating peptides: impact on GAG-dependent internalisation and direct translocation

M. Amoura, F. Illien, A. Joliot, K. Guitot, J. Offer, S. Sagan and F. Burlina, Chem. Commun., 2019, 55, 4566 DOI: 10.1039/C9CC01265F

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements