Issue 45, 2019
From the journal:

Chemical Communications

Precise ricin A-chain delivery by Golgi-targeting carbon dots†

Chun Hong Li, ORCID logo a   Rong Sheng Li, ORCID logo b   Chun Mei Li, ORCID logo b   Cheng Zhi Huang ORCID logo *ab  and  Shu Jun Zhen ORCID logo *a  

* Corresponding authors

a Key Laboratory of Luminescence and Real-Time Analytical Chemistry (Southwest University), Ministry of Education, College of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, P. R. China
E-mail: zsj@swu.edu.cn
Fax: +86 2368367257
Tel: +86 2368254059

b College of Pharmaceutical Sciences, Southwest University, Chongqing 400715, P. R. China
E-mail: chengzhi@swu.edu.cn
Fax: +86 2368367257
Tel: +86 2368254659

Abstract

A precise ricin A-chain (RTA) delivery system was constructed by coupling RTA to carbon dots (CDs) with a distinctive capacity for Golgi targeting. The rational design shows efficient internalization and an exact pathway to the cytoplasm for RTA to exert its real toxic action since it could avoid lysosome degradation.

Graphical abstract: Precise ricin A-chain delivery by Golgi-targeting carbon dots

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Article information

DOI
https://doi.org/10.1039/C9CC01599J
Article type
Communication
Submitted
26 Feb 2019
Accepted
09 May 2019
First published
10 May 2019

Chem. Commun., 2019,55, 6437-6440

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Precise ricin A-chain delivery by Golgi-targeting carbon dots

C. H. Li, R. S. Li, C. M. Li, C. Z. Huang and S. J. Zhen, Chem. Commun., 2019, 55, 6437 DOI: 10.1039/C9CC01599J

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