Issue 48, 2019

A chiral switch: balancing between equilibrium and non-equilibrium states

Abstract

Herein we introduce a “chiral switch” – a sequence of operations that alternate between equilibrium and non-equilibrium conditions to switch the absolute configuration of a chiral center. The generality and practical potential of the technique are demonstrated with three unnatural α-amino acid precursors.

Graphical abstract: A chiral switch: balancing between equilibrium and non-equilibrium states

Supplementary files

Article information

Article type
Communication
Submitted
26 Apr 2019
Accepted
22 May 2019
First published
22 May 2019

Chem. Commun., 2019,55, 6910-6913

A chiral switch: balancing between equilibrium and non-equilibrium states

I. Baglai, M. Leeman, B. Kaptein, R. M. Kellogg and W. L. Noorduin, Chem. Commun., 2019, 55, 6910 DOI: 10.1039/C9CC03250A

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