Issue 25, 2019
From the journal:

CrystEngComm

Characterization of drug–drug salt forms of metformin and aspirin with improved physicochemical properties†

Wen-Xiu Zhou,ab   Hong-Wei Zhao,ab   Huan-Huan Chen,ab   Zai-Yong Zhanga  and  Dong-Ying Chen ORCID logo *a  

* Corresponding authors

a Research Center for Pharmaceutical Quality Control and Solid-State Chemistry, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Rd. Zuchongzhi, Zhangjiang Hi-Tech Park, Shanghai, China
E-mail: dychen@simm.ac.cn

b University of Chinese Academy of Sciences, Beijing 100049, China

Abstract

A drug–drug salt was prepared consisting of metformin and aspirin with two crystalline phases characterized. A hydrophilic surface induced recrystallization mechanism was supposed for the transition from anhydrate to hemihydrate. The modulated solubility properties of the dual drug would help to overcome the associated gastrointestinal side effects to some extent.

Graphical abstract: Characterization of drug–drug salt forms of metformin and aspirin with improved physicochemical properties

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Article information

DOI
https://doi.org/10.1039/C9CE00377K
Article type
Communication
Submitted
14 Mar 2019
Accepted
08 May 2019
First published
10 May 2019

CrystEngComm, 2019,21, 3770-3773

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Characterization of drug–drug salt forms of metformin and aspirin with improved physicochemical properties

W. Zhou, H. Zhao, H. Chen, Z. Zhang and D. Chen, CrystEngComm, 2019, 21, 3770 DOI: 10.1039/C9CE00377K

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