Formal [4 + 1] cycloaddition of in situ generated 1,2-diaza-1,3-dienes with diazo esters: facile approaches to dihydropyrazoles containing a quaternary center

Bo Chen; Wen-Dao Chu; Quan-Zhong Liu

doi:10.1039/C8RA08909D

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Formal [4 + 1] cycloaddition of in situ generated 1,2-diaza-1,3-dienes with diazo esters: facile approaches to dihydropyrazoles containing a quaternary center

Bo Chen, Wen-Dao Chu and Quan-Zhong Liu
RSC Adv., 2019,9, 1487-1490
DOI: 10.1039/C8RA08909D, Paper

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Abstract | Cited by

A Cu(II)/bisoxazoline ligand-promoted formal [4 + 1] cycloaddition of diazo esters with azoalkenes formed in situ has been developed. This strategy provides a potential protocol for the construction of dihydropyrazoles containing a quaternary center with good to excellent yields.

Graphical abstract: Formal [4 + 1] cycloaddition of in situ generated 1,2-diaza-1,3-dienes with diazo esters: facile approaches to dihydropyrazoles containing a quaternary center

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