Issue 21, 2020

Nano and microscale delivery platforms for enhanced oral peptide/protein bioavailability

Abstract

In recent years, peptide/protein drugs have attracted considerable attention owing to their superior targeting and therapeutic effect and fewer side effects compared with chemical drugs. Oral administration modality with enhanced patient compliance is increasingly being recognized as an ideal route for peptide/protein delivery. However, the limited permeation efficiency and low oral bioavailability of peptide/protein drugs significantly hinder therapeutic advances. To address these problems, various nano and microscale delivery platforms have been developed, which offer significant advantages in oral peptide/protein delivery. In this review, we briefly introduce the transport mechanisms of oral peptide/protein delivery and the primary barriers to this delivery process. We also highlight the recent advances in various nano and microscale delivery platforms designed for oral peptide/protein delivery. We then summarize the existing strategies used in these delivery platforms to improve the oral bioavailability and permeation efficiency of peptide/protein therapeutics. Finally, we discuss the major challenges faced when nano and microscale systems are used for oral peptide/protein delivery. This review is expected to provide critical insight into the design and development of oral peptide/protein delivery systems with significant therapeutic advances.

Graphical abstract: Nano and microscale delivery platforms for enhanced oral peptide/protein bioavailability

Article information

Article type
Review Article
Submitted
11 Jul 2020
Accepted
03 Sep 2020
First published
04 Sep 2020

Biomater. Sci., 2020,8, 5804-5823

Nano and microscale delivery platforms for enhanced oral peptide/protein bioavailability

T. Tong, L. Wang, X. You and J. Wu, Biomater. Sci., 2020, 8, 5804 DOI: 10.1039/D0BM01151G

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