Human serum albumin as an intrinsic signal amplification amplifier for ultrasensitive assays of the prostate-specific antigen in human plasma

Le Yang; Jing Zheng; Zhen Zou; Haiyan Cai; Peng Qi; Zhihe Qing; Qi Yan; Liping Qiu; Weihong Tan; Ronghua Yang

doi:10.1039/C9CC08501G

Human serum albumin as an intrinsic signal amplification amplifier for ultrasensitive assays of the prostate-specific antigen in human plasma†

Le Yang,‡^a Jing Zheng,‡^a Zhen Zou,

*^b Haiyan Cai,^c Peng Qi,^b Zhihe Qing,

^b Qi Yan,^b Liping Qiu,^a Weihong Tan

^a and Ronghua Yang

*^ab

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* Corresponding authors

^a State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410114, P. R. China
E-mail: kobe474779970@126.com, Yangrh@pku.edu.cn

^b School of Chemistry and Food Engineering, Changsha University of Science and Technology, Changsha 410082, P. R. China

^c Department of Pathophysiology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, School of Medicine, Shanghai JiaoTong University, Shanghai 200240, China

Abstract

As the most abundant protein in blood, human serum albumin (HSA) is usually regarded as an interferent in clinical molecular diagnosis. Herein, we report that HSA is an endogenous signal amplifier for the detection of the prostate-specific antigen (PSA) in human plasma. This is the first study to utilize intrinsic biological components as the signal amplifier in blood tests.

Chemical Communications

Human serum albumin as an intrinsic signal amplification amplifier for ultrasensitive assays of the prostate-specific antigen in human plasma†

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Human serum albumin as an intrinsic signal amplification amplifier for ultrasensitive assays of the prostate-specific antigen in human plasma

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