Issue 11, 2020, Issue in Progress
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RSC Advances

Photostable near-infrared-absorbing diradical-platinum(ii) complex solubilized by albumin toward a cancer photothermal therapy agent†

Ryota Sawamura,a   Masataka Sato,a   Atsuko Masuya-Suzukia  and  Nobuhiko Iki ORCID logo *a  

* Corresponding authors

a Graduate School of Environmental Studies, Tohoku University, 6-6-07, Aramaki-Aoba, Aoba-ku, Sendai, Japan
E-mail: iki@tohoku.ac.jp
Fax: +81-22-795-7293

Abstract

A hydrophobic diradical-platinum(II) complex was solubilized in aqueous solutions by using bovine serum albumin and exhibited photothermal conversion under near-infrared (NIR) light irradiation. The complex was introduced into cancer cells and induced cell death upon absorption of NIR. These results imply that the complex can function as a photothermal therapeutic agent.

Graphical abstract: Photostable near-infrared-absorbing diradical-platinum(ii) complex solubilized by albumin toward a cancer photothermal therapy agent

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Article information

DOI
https://doi.org/10.1039/D0RA00652A
Article type
Paper
Submitted
11 Dec 2019
Accepted
03 Feb 2020
First published
11 Feb 2020
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2020,10, 6460-6463

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Photostable near-infrared-absorbing diradical-platinum(II) complex solubilized by albumin toward a cancer photothermal therapy agent

R. Sawamura, M. Sato, A. Masuya-Suzuki and N. Iki, RSC Adv., 2020, 10, 6460 DOI: 10.1039/D0RA00652A

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