Using the updated module boundary of polyketide assembly lines, modules from the pikromycin synthase were recombined into engineered synthases that furnish an enantiomeric pair of 2-stereocenter triketide lactones at >99% ee with yields up to 0.39 g per liter of E. coli K207-3 in shake flasks.
T. Miyazawa, B. J. Fitzgerald and A. T. Keatinge-Clay, Chem. Commun., 2021, 57, 8762 DOI: 10.1039/D1CC03073F
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