An efficient approach to synthesize α-keto aldehydes was established through selective oxidation of α-hydroxy ketones catalyzed by Cu(I) using oxygen as oxidant. A wide array of α-keto aldehydes was prepared with isolated yields of up to 87%. The potential utilization of this reaction was evaluated by gram-scale reactions and synthetic applications.
S. Zheng, W. Smit, A. Spannenberg, S. Tin and J. G. de Vries, Chem. Commun., 2022, 58, 4639 DOI: 10.1039/D2CC00773H
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