Facile iodine-promoted synthesis of bis(1-imidazo[1,5-a]pyridyl)arylmethanes and exploration of applications

Ban Van Phuc; Nina Thi Nguyen; Nguyen Thi Hong Van; Thanh Luan Nguyen; Van Ha Nguyen; Cong Minh Tran; Hien Nguyen; Minh Tho Nguyen; Tran Quang Hung; Tuan Thanh Dang

doi:10.1039/D2CC05419A

Facile iodine-promoted synthesis of bis(1-imidazo[1,5-a]pyridyl)arylmethanes and exploration of applications†

Ban Van Phuc,^a Nina Thi Nguyen,^b Nguyen Thi Hong Van,^b Thanh Luan Nguyen,^b Van Ha Nguyen,^b Cong Minh Tran,^c Hien Nguyen,^c Minh Tho Nguyen,

^d Tran Quang Hung

*^ae and Tuan Thanh Dang

*^b

Author affiliations

* Corresponding authors

^a Institute of Chemistry, Vietnamese Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Hanoi, Vietnam
E-mail: tqhung@ich.vast.vn

^b Faculty of Chemistry, VNU-Hanoi University of Science, 19 Le Thanh Tong, Hanoi, Vietnam
E-mail: dangthanhtuan@hus.edu.vn

^c Faculty of Chemistry, Hanoi National University of Education, 136 Xuan Thuy, Cau Giay, Hanoi, Vietnam

^d Department of Chemistry, KU Leuven, Celestijnenlaan 200F, Leuven B-3001, Belgium

^e Graduate University of Science and Technology, Vietnamese Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Hanoi, Vietnam

Abstract

A practical strategy for the iodine-promoted synthesis of bis(1-imidazo[1,5-a]pyridyl)arylmethane and its derivatives has been developed. These compounds exhibit high cytotoxicity toward various cancer cell lines and moreover they are promising ligands for the Cu-catalysed synthesis of quinolines.

Chemical Communications

Facile iodine-promoted synthesis of bis(1-imidazo[1,5-a]pyridyl)arylmethanes and exploration of applications†

Abstract

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Facile iodine-promoted synthesis of bis(1-imidazo[1,5-a]pyridyl)arylmethanes and exploration of applications

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