In vitro cytotoxicity of Mn(I) and Ru(II) carbonyls with a diphenyl pyridyl phosphine coligand towards leukaemia

Ahmed M. Mansour; Rabaa M. Khaled; Krzysztof Radacki; Zeina Younes; Mariam Gamal; Beatrice Guirguis; Gamal A. E. Mostafa; Essam A. Ali; Ola R. Shehab

doi:10.1039/D3DT01798B

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In vitro cytotoxicity of Mn(i) and Ru(ii) carbonyls with a diphenyl pyridyl phosphine coligand towards leukaemia†

Ahmed M. Mansour,

*^a Rabaa M. Khaled,

^a Krzysztof Radacki,

^b Zeina Younes,^c Mariam Gamal,^c Beatrice Guirguis,^c Gamal A. E. Mostafa,^d Essam A. Ali^d and Ola R. Shehab

Author affiliations

* Corresponding authors

^a Department of Chemistry, Faculty of Science, Cairo University, Gamma Street, Giza, Cairo 12613, Egypt
E-mail: mansour@sci.cu.edu.eg, inorganic_am@yahoo.com

^b Institut für Anorganische Chemie, Julius-Maximilians-Universität Würzburg, Am Hubland, D-97074 Würzburg, Germany

^c Department of Biotechnology, Faculty of Science, Cairo University, Gamma Street, Giza, Cairo 12613, Egypt

^d Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia

Abstract

Human acute monocytic leukaemia cells were tested under both dark and light conditions for their susceptibility to Mn(I) and Ru(II) carbonyl complexes with a diphenyl pyridyl phosphine coligand. The Ru(II) complex (IC₅₀ = 7.13 ± 0.8 μM) displayed higher outstanding potency against leukaemia than the Mn(I) analogue (54.58 ± 4.1 μM) in the dark and both complexes were completely harmless to healthy mouse bone marrow cells.

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DOI: https://doi.org/10.1039/D3DT01798B
Article type: Communication
Submitted: 10 Jun 2023
Accepted: 08 Jul 2023
First published: 19 Jul 2023

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Dalton Trans., 2023,52, 10286-10293

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In vitro cytotoxicity of Mn(I) and Ru(II) carbonyls with a diphenyl pyridyl phosphine coligand towards leukaemia

A. M. Mansour, R. M. Khaled, K. Radacki, Z. Younes, M. Gamal, B. Guirguis, G. A. E. Mostafa, E. A. Ali and O. R. Shehab, Dalton Trans., 2023, 52, 10286 DOI: 10.1039/D3DT01798B

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In vitro cytotoxicity of Mn(i) and Ru(ii) carbonyls with a diphenyl pyridyl phosphine coligand towards leukaemia†

Abstract

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In vitro cytotoxicity of Mn(I) and Ru(II) carbonyls with a diphenyl pyridyl phosphine coligand towards leukaemia

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