Remote stereocentres do not disrupt the stereochemical coupling in homochiral [M2L3] helicates and [M4L6] tetrahedra

Abstract

Despite the use of achiral ligands, the vast majority of metallosupramolecular assemblies containing octahedral tris-bidentate metal centres show strong stereochemical communication between metal centres, generally resulting in homochiral assemblies even though they are statistically disfavoured. Here we show that when resolved stereocentres are attached to the central part of a quaterpyridine ligand, the stereochemical coupling from this centre is insufficient to disrupt the strong stereochemical communication between metal centres in both [M₂L₃] helicates and [M₄L₆] tetrahedra.