A dual-targeted trinity of antibody–peptide–drug delivery consortium to combat HER2+ tumor

Yuna Shang; Jiayu Wang; Yinyin Feng; Zhengyu Liu; Jiayi Lu; Sijia Deng; Li Li; Hongxu Zhang; Liantao Li; Zhongyan Wang; Zhimou Yang

doi:10.1039/D4CC05115G

A dual-targeted trinity of antibody–peptide–drug delivery consortium to combat HER2+ tumor†

Yuna Shang,^a Jiayu Wang,^a Yinyin Feng,^a Zhengyu Liu,^a Jiayi Lu,^a Sijia Deng,^d Li Li,^a Hongxu Zhang,^a Liantao Li,*^d Zhongyan Wang

*^c and Zhimou Yang

*^bd

Author affiliations

* Corresponding authors

^a Academy of Interdisciplinary Studies on Intelligent Molecules, Tianjin Key Laboratory of Structure and Performance for Functional Molecules, College of Chemistry, Tianjin Normal University, Tianjin 300387, P. R. China

^b Zhejiang Key Laboratory of Intelligent Cancer Biomarker Discovery and Translation, The First Affiliated Hospital, Wenzhou Medical University, Wenzhou 325035, Zhejiang, P. R. China
E-mail: yangzm@nankai.edu.cn

^c State Key Laboratory of Advanced Medical Materials and Devices, Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Key Laboratory of Radiopharmacokinetics for Innovative Drugs, Tianjin Institutes of Health Science, Institute of Radiation Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300192, P. R. China
E-mail: wangzhongyan@irm-cams.ac.cn

^d Center of Clinical Oncology, The Affiliated Hospital of Xuzhou Medical University, Jiangsu Center for the Collaboration and Innovation of Cancer Biotherapy, Xuzhou Medical University, Xuzhou, Jiangsu 221004, P. R. China
E-mail: liliantao@xzhmu.edu.cn

Abstract

We pioneered a dual-targeted trinity of antibody–peptide–drug delivery consortium to combat HER2+ tumors. This innovative approach leverages the self-assembly of peptides with high affinity to antibodies to create nanofibers for antibody encapsulation, offering a novel strategy in antibody drug delivery.

Chemical Communications

A dual-targeted trinity of antibody–peptide–drug delivery consortium to combat HER2+ tumor†

Abstract

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A dual-targeted trinity of antibody–peptide–drug delivery consortium to combat HER2+ tumor

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