A phytic acid-based CoMn bimetallic metal–organic aerogel (PA–CoMn-1 : x : 2 − x) as a modifier for electrochemical detection of non-steroidal anti-inflammatory drug 4-acetaminophenol

Abstract

Metal phosphides and phosphate-based materials have received significant attention due to their high electrocatalytic activity, adjustable structure composition and stability. Herein, we introduce a phytic acid-based CoMn bimetallic metal–organic (PA–CoMn) aerogel as an electrode modifier, derived from PA and mixed transition metal ions (Co²⁺, Mn²⁺). We explored its performance in the sensitive sensing of non-steroidal anti-inflammatory drug 4-acetaminophenol (4-AP) for the first time. We investigated the electrochemical behavior of the modified screen-printed carbon electrode (SPCE) by cyclic voltammetry (CV) and differential pulse voltammetry (DPV). The PA–CoMn-1 : 1.5 : 0.5 aerogel/Nafion/SPCE proved to be highly sensitive and selective towards the detection of 4-AP. A double linear response was recorded for 4-AP over the range of 1 μM to 0.1 mM and lower detection limits (LOD) of 0.2133 μM. The applicability of the PA–CoMn-1 : 1.5 : 0.5 aerogel/Nafion/SPCE in the detection of 4-AP in commercial drug samples with good recoveries was investigated, confirming the great potential of PA–CoMn-1 : 1.5 : 0.5 aerogel/SPCE in clinical applications.