A radical approach towards polarity-reversed para-substitution of electron-deficient arenes

Abstract

We have developed a protocol for polarity-reversed para-substitution of electron-deficient arenes. In order to achieve desired reactivity and selectivity for a broad range of substrates, the dual pronged strategy is essential. Furthermore, this approach has also shown promise in perfluoroalkylation of arenes. Control experiments and computational studies provide a mechanistic insight for the observed selectivity. The potential for drug design synthesis has been showcased by this economical and ecofriendly method that provides access to a variety of building blocks.