Nickel-catalyzed reductive cross-coupling of difluoromethylated secondary alkyl bromides with organohalides

Abstract

We present a highly efficient and versatile nickel-catalyzed protocol for the reductive cross-coupling of unactivated CF₂H-substituted electrophiles with a wide variety of aryl and alkenyl halides. This novel approach offers high catalytic reactivity and broad functional group compatibility, enabling late-stage fluoroalkylation of drug molecules.