Issue 42, 2012

An organocatalytic Michael-aldol cascade: formal [3+2] annulation to construct enantioenriched spirocyclic oxindole derivatives

Abstract

An efficient organocatalytic Michael-aldol cascade reaction for the asymmetric synthesis of spirocyclic oxindole derivatives fused with tetrahydrothiophenes has been developed through a formal [3+2] annulation strategy.

Graphical abstract: An organocatalytic Michael-aldol cascade: formal [3+2] annulation to construct enantioenriched spirocyclic oxindole derivatives

Supplementary files

Article information

Article type
Communication
Submitted
09 Feb 2012
Accepted
05 Mar 2012
First published
05 Mar 2012

Chem. Commun., 2012,48, 5160-5162

An organocatalytic Michael-aldol cascade: formal [3+2] annulation to construct enantioenriched spirocyclic oxindole derivatives

S. Duan, Y. Li, Y. Liu, Y. Zou, D. Shi and W. Xiao, Chem. Commun., 2012, 48, 5160 DOI: 10.1039/C2CC30931A

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