Issue 4, 2014

A general method for asymmetric arylation and vinylation of silyl ketene acetals

Abstract

A new biarylmonophosphine was developed for highly asymmetric arylation and vinylation of silyl enolates of acyclic esters with good generality. The new stereocenters α to the ester groups were formed in high enantiomeric excess. The method was applied to the asymmetric synthesis of Profen drugs on a gram scale.

Graphical abstract: A general method for asymmetric arylation and vinylation of silyl ketene acetals

Supplementary files

Article information

Article type
Research Article
Submitted
24 Jan 2014
Accepted
21 Feb 2014
First published
18 Mar 2014

Org. Chem. Front., 2014,1, 365-367

Author version available

A general method for asymmetric arylation and vinylation of silyl ketene acetals

J. Yang and J. (. Zhou, Org. Chem. Front., 2014, 1, 365 DOI: 10.1039/C4QO00027G

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements