Issue 1, 2015
From the journal:

Chemical Communications

Chemoselective per-O-trimethylsilylation and homogeneous N-functionalisation of amino sugars†

A. Abragam Joseph,ab   Vijay M. Dhurandhare,acd   Chun-Wei Chang,ac   Ved Prakash Verma,a   Girija Prasad Mishra,ae   Chiao-Chu Ku,a   Chun-Cheng Lin*b  and  Cheng-Chung Wang*ac  

* Corresponding authors

a Institute of Chemistry, Academia Sinica, Taipei 115, Taiwan
E-mail: wangcc@chem.sinica.edu.tw
Fax: +886-2-2783-1237
Tel: +886-2-2789-8618

b Department of Chemistry, National Tsing Hua University, Hsinchu 300, Taiwan
E-mail: cclin66@mx.nthu.edu.tw
Fax: +886-2-2783-1237
Tel: +886-2-2789-8618

c Chemical Biology and Molecular Biophysics Program, Taiwan International Graduate Program, Academia Sinica, Taipei 115, Taiwan

d Institute of Bioinformatics and Structural Biology, National Tsing Hua University, Hsinchu 300, Taiwan

e Genomics Research Center, Academia Sinica, Taipei 115, Taiwan

Abstract

A highly efficient CH3CN-promoted hexamethyldisilazane per-O-trimethylsilylation of amino sugars was developed. Its applications in homogenous N-functionalisation and a concise synthesis of glucosamine 6-phosphate are described.

Graphical abstract: Chemoselective per-O-trimethylsilylation and homogeneous N-functionalisation of amino sugars

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Article information

DOI
https://doi.org/10.1039/C4CC06645F
Article type
Communication
Submitted
23 Aug 2014
Accepted
04 Nov 2014
First published
04 Nov 2014

Chem. Commun., 2015,51, 104-106

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Chemoselective per-O-trimethylsilylation and homogeneous N-functionalisation of amino sugars

A. A. Joseph, V. M. Dhurandhare, C. Chang, V. P. Verma, G. P. Mishra, C. Ku, C. Lin and C. Wang, Chem. Commun., 2015, 51, 104 DOI: 10.1039/C4CC06645F

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