Issue 35, 2017
From the journal:

Chemical Communications

Phase-transfer catalyzed asymmetric synthesis of α,β-unsaturated γ,γ-disubstituted γ-lactams†

Alexander Arlt,a   Hideaki Toyama,a   Koji Takada,a   Takuya Hashimotoa  and  Keiji Maruoka ORCID logo *a  

* Corresponding authors

a Department of Chemistry, Graduate School of Science, Kyoto University, Sakyo, Kyoto, Japan
E-mail: maruoka@kuchem.kyoto-u.ac.jp

Abstract

The direct enantioselective vinylogous Michael addition of unsaturated γ-monosubstituted γ-lactams was realized by using chiral phase-transfer catalysis as a means to give enantioenriched γ,γ-disubstituted γ-lactams.

Graphical abstract: Phase-transfer catalyzed asymmetric synthesis of α,β-unsaturated γ,γ-disubstituted γ-lactams

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Article information

DOI
https://doi.org/10.1039/C7CC01058C
Article type
Communication
Submitted
10 Feb 2017
Accepted
31 Mar 2017
First published
31 Mar 2017

Chem. Commun., 2017,53, 4779-4782

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Phase-transfer catalyzed asymmetric synthesis of α,β-unsaturated γ,γ-disubstituted γ-lactams

A. Arlt, H. Toyama, K. Takada, T. Hashimoto and K. Maruoka, Chem. Commun., 2017, 53, 4779 DOI: 10.1039/C7CC01058C

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