Communication
Redox-neutral, metal-free tryptophan labeling of polypeptides in hexafluoroisopropanol (HFIP)
This work translated the preceding metal-catalyzed tryptophan modification method into a metal-free process, enabling efficient labeling of peptides, proteins, and even cell lysates in hexafluoroisopropanol (HFIP).
Paper
A nanoengineered tandem nitroreductase: designing a robust prodrug-activating nanoreactor
Our study demonstrates that encapsulating tandem nitroreductase NfsB within encapsulins, along with pore mutations, enhances enzyme activity, with cryo-EM revealing its structural architecture and multiple pore states.
Paper
Expanding the repertoire of GalNAc analogues for cell-specific bioorthogonal tagging of glycoproteins
Demonstrating the use of azide-containing GalNAc analogues in conjunction with an engineered metabolic pathway to study glycosylation cell-specifically.
Paper
Superoxide-responsive quinone methide precursors (QMP-SOs) to study superoxide biology by proximity labeling and chemoproteomics
QMP-SOs are molecular probes capable of proximity labeling of proteins in a superoxide-dependent manner. This enables fluorescence imaging of superoxide and profiling proteins associated with superoxide biology by chemoproteomics.
Paper
Reverse transcription as key step in RNA in vitro evolution with unnatural base pairs
Unnatural base pairs (UBPs) augment the chemical diversity of artificial nucleic acids and can enable the generation of new aptamers and catalytic nucleic acids by in vitro selection. Reverse transcription of UBPs as key step during RNA in vitro selection is investigated.
About this collection
RSC Chemical Biology is proud to present this collection of invited contributions from early career researchers who are making significant contributions to the field of chemical biology. Congratulations to all of the featured researchers!
New articles will be added to this collection as they are published.