Themed collection Food & Function HOT Articles 2024

Polymorphisms in key genes in the vitamin D metabolic pathway affect susceptibility to cardiovascular disease (CVD) and play potential roles in the pathogenesis of CVD.

Plant-derived extracellular vesicles (PDEVs) are nanoscale vesicles released from plant cells into the extracellular space.

Emerging evidence highlights that eugenol exhibits significant biological activities across various conditions, suggesting it is a promising nutritional supplement with both flavoring properties and therapeutic potential.

The purpose of this study is to investigate the impact of dietary fibre on the mental health and cognitive function of children and adolescents.

Quercetin reverses the expression of abnormal genes by regulating DNA methylation, and is an important regulator of gene transcription in tumorigenesis. The use of nanoscale delivery of quercetin increases its bioavailability in cancer therapy.

Edible insect species are attracting the attention of the food industry and consumers in Western societies due to their high content and quality of protein, which is starting to be evaluated as source of peptides with immunomodulatory properties.

This study aimed to explore the lipid-lowering effect and the mechanism of action of the milk fat globule membrane (MFGM) in obese mice.

We developed an extensively hydrolyzed infant formula (EHF) with a protein composition similar to breast milk (whey protein-to-casein ratio of 6 : 4) and evaluated its sensitization in vitro and in vivo.

Effects of hydroponic cultivation with enriched concentrations of magnesium (+Mg), manganese (+Mn), combinations of +Mg and +Mn, or decreased concentrations of these minerals (control) on the chemical/bioactive attributes of basil, were investigated.

TLPL promoted the production of Lactobacillus in myelosuppressed mice, and promoted the haematopoiesis of bone marrow cells via the gut-bone marrow axis.

Limosilactobacillus fermentum DACN611 degraded ethanol through adaptive metabolic changes under ethanol stress conditions and by promoting alcohol dehydrogenase and acetaldehyde dehydrogenase activities in gastric and hepatic tissues.

Green tea polyphenols (GTP), an important phytochemical in the daily human diet, bind to various cellular receptors and exert anti-inflammatory and antioxidant benefits.

A complex of Lactiplantibacillus plantarum CCFM8661 and chondroitin sulfate alleviates lead toxicity in lead-exposed mice.

The effects of fat-free milk, fat-free yogurt, and reduced-fat cheese on brown adipose tissue (BAT) thermogenesis in high-fat diet (HFD)-induced obese mice.

Enzymatic proteomic profiles were examined to comprehend the predominant enzymes involved in the flavor development of salted shrimp paste influenced by Bacillus subtilis K-C3 inoculation (Inoc), compared to those without inoculation (CON).

Any type of KGM intake pattern could reduce body weight and fat mass in obese mice. However, KGM sol has the most significant effect on controlling blood glucose and blood lipid.

The onset and progression of ulcerative colitis (UC) are intricately linked to the worsening of intestinal inflammation, an imbalance in oxidative stress, and impairment of the intestinal mucosal barrier.

Nine core gut bacteria (M9) can successfully form stable and complex multi-species biofilms on wheat fiber through a dynamic fermentation method.

SFN alleviated IR via the Bacteroides and Lactobacillus-SCFAs–GPR41/43-GLP1 axis and protected the intestinal mucosal barrier, thereby, reducing the inflammatory response.

Aberrant glycosylation induced by LPS in the microglial glycocalyx can be restored by dietary and gut microbe-derived fatty acids highlighting their potential to relieve neuroinflammation.

Circulating metabolites resulting from colonic metabolism of dietary (poly)phenols are highly abundant in the bloodstream, though still marginally explored, particularly concerning their brain accessibility.

Pomegranate supplemetation decreased fat depots, counteracted the dyslipidemia caused by fructose and improved markers of liver injury. Microbial metabolites from pomegranate may be responsible for these health benefits.

Thyme polyphenol-rich extract effectively mitigate HFD- induced NAFLD by modulating the gut-liver axis, specifically targeting the gut microbiota and bile acid metabolism.

The carboxymethylated Lycium barbarum seed dreg insoluble dietary fiber (IDFs) significantly alleviated HFD-induced dyslipidemia, inflammation and hepatocyte degeneration, and ameliorated gut dysbiosis and increased SCFAs levels in obese mice.

Dietary macronutrient quality and asthenozoospermia risk.

The efficacy and safety of galacto-oligosaccharides (GOS) in treating functional constipation were evaluated in a four-week randomized, double-blind clinical trial on 63 patients who met Rome IV criteria (34 GOS, 29 placebo group).

Fx effectively prevents LPS-induced intestinal barrier injury via inhibiting intestinal inflammation and oxidative stress.

Age-related macular degeneration (AMD) is a prominent cause of vision loss among the elderly, and the treatment options for dry AMD (dAMD) are severely limited.

A bergamot-based beverage does not affect glucose, lipid and inflammatory biomarkers of cardiometabolic risk in healthy subjects.

Red-fleshed apples (RFA), improve endothelial function and decrease inflammation. RFA induce more improvements in inflammation than aronia infusion (AI), whereas AI improves lipid profile. RFA, white-fleshed apples and AI modulate immune system.

Carbohydrates are an important macronutrient whose processing and digestive fate can have numerous beneficial or adverse effects on consumer health.

Multi-site acylation of troxerutin can solve the problems of cytotoxicity and rapid hydrolysis of ester bonds caused by mono-acylation and increase cellular uptake.

A natural aging mouse model can exhibit physiological characteristics that closely resemble those of human aging.

Miltin, a dairy-derived peptide, activates the thermogenic programs in brown and white adipocytes by directly interacting with GADD45r.

Pu-erh tea can enhance the efficacy of levodopa in treating Parkinson's disease by inhibiting COMT activity and improving levodopa's pharmacokinetic behavior in rats.

Gamma-aminobutyric acid (GABA) is the predominant amino acid in litchi pulp, known for its neuroregulatory effects and anti-inflammatory properties.

This study aimed to assess the impact of Lactobacillaceae (L or H represents a low or high dose), inulin (I), and polydextrose (P) combined with aerobic exercise (A) on the composition of the gut microbiota and metabolic profiles in db/db mice.

Mechanisms of B. pseudocatenulatum NCU-08 in mitigating aging via the microbiota–gut–brain axis.

Designing a cereal-based product with added nutritional value and health-enhancing effects.

In this randomized placebo-controlled crossover study, we evaluated whether previously reported cardiovascular benefits of plant-derived inorganic nitrate via NO translate into improved vascular function and blood pressure-lowering in middle-aged and older men and women with treated hypertension.

Gastritis is a common disease characterized by gastric ulcers and severe bleeding.

Frequent consumption of fried foods has been strongly associated with a higher risk of anxiety and depression, particularly among young individuals.

Lipoic acid (LA) ameliorated acrylamide (ACR)-induced social impairment in adolescent mice. Lipoic acid (LA) reshaped gut microbiota and its metabolites. Lipoic acid (LA) regulated serum amino acid level.

Tetrabromobisphenol A (TBBPA) is a global pollutant. When TBBPA is absorbed by the body through various routes, it can have a wide range of harmful effects on the body.

Lactiplantibacillus plantarum D-9 shows neuroprotective effects on anxiety- and depression-like disorders in CUMS mice by modulating tryptophan metabolism and the gut microbiota.

Two novel Kokumi peptides, identified from Agaricus bisporus via sensory and computer analyses, potentially enhance umami taste and reduce salt intake.

We studied how protein intake and sources affect selective glomerular hypofiltration syndrome patients' mortality. More protein (mainly from non-red meat) lowered death risk by 40% (all-cause) and 88% (cardiovascular).