Themed collection Integrative Biology Most Downloaded Articles

This review highlights the application of recent innovations in microtechnologies, biomaterials, and imaging tools for probing cell–ECM interactions.

Biomaterial interfaces can present soluble and physical cues on the nano- and micro-scale to control T cell behaviour.

Aptamer-functionalized nano/micro-materials have enabled efficient cell-specific recognition, isolation, release and complete subsequent characterization for future clinical therapy guidance.

We synthesize topics often presented in dedicated reviews to argue that network medicine should be truly interdisciplinary to revolutionize medicine.

The development of CRISPR-Cas9 technology has revolutionized our ability to edit DNA and to modulate expression levels of genes of interest, thus providing powerful tools to accelerate the precise engineering of a wide range of organisms.

This review provides a framework for development of on-chip liquid biopsy platforms for capture, detection, and analysis of circulating tumor cells.

A combined approach involving microfluidic pulsatile stimulation and mathematical modeling has led to deciphering of hidden/unknown temporal motifs in several mammalian signaling pathways and has provided mechanistic insights, including how these motifs process temporal signals and govern fate regulation.

Creating vascular networks in tissues is crucial for tissue engineering.

We provide a dynamic perspective of how nanotopography regulate adhesions at the single molecular level.

The effects of systematic microenvironmental changes on melanoma drug responsiveness were assessed and found to depend on the stage of progression and culture conditions.