Review Article
Recent progress in chemoenzymatic synthesis of human glycans
This work reviewed the recent progress in the chemoenzymatic synthesis of human glycans and provides insights into the limitations and perspectives of the current methods.
Glycosphingolipids: from metabolism to chemoenzymatic total synthesis
GSL biosynthesis pathways and the enzymes involved, recombinant enzymes applied to GSL synthesis, and recent progress in related synthetic strategies are reviewed to help develop new enzymes and methods for efficient chemoenzymatic GSL synthesis.
Review Article
Recent developments in the enzymatic modifications of steroid scaffolds
This review highlights the recent advancements in the enzymatic modifications of steroid scaffolds, emphasizing enzymatic hydroxylation, ketoreduction, dehydrogenation, enzymatic cascade reactions, and other modifications.
FlkO, a penicillin-binding protein-type thioesterase in cyclofaulknamycin biosynthesis
In vitro studies of FlkO, a new penicillin-binding protein thioesterase, demonstrated its peptide-cyclizing activity and substrate scope.
Accepted Manuscript -
Paper
One-pot hydroaminomethylation of an alkene under formation of primary amines by combining hydroformylation at elevated syngas pressure and biocatalytic transamination in water
Enzymatic synthesis of N-formylated sialosides via a five-enzyme cascade
Here we report an enzymatic approach to synthesize N-formylneuraminic acid (Neu5Fo) containing sialosides, through a five-enzyme cascade.
A bifunctional Pasteurella multocida β1–3-galactosyl/N-acetylgalactosaminyltransferase (PmNatB) for the highly efficient chemoenzymatic synthesis of disaccharides
A single-catalytic-domain bifunctional bacterial β1–3-galactosyl and β1–3-N-acetylgalactosaminyltransferase PmNatB has been characterized and used for the efficient one-pot multienzyme (OPME) chemoenzymatic synthesis of diverse disaccharides.
About this collection
This themed issue guest edited by Professor Hongzhi Cao (Ocean University of China), Professor Suvarn Kulkarni (IIT Bombay) and Professor Hiroki Oguri (University of Tokyo) is dedicated to the emerging advancements in chemoenzymatic synthesis across a wide array of natural products. This integrative synthetic approach not only harnesses the power of enzymes but also leverages the versatility of chemical synthesis regarding substrate design and product diversification.
New articles will be added to the collection upon publication. Please return to this page frequently to see the collection grow.