Cooperative iridium and organocatalysis: a new frontier in asymmetric chemistry
Cooperative iridium-organocatalysis has emerged as a valuable tool for producing biologically active chiral molecules from easily accessible starting materials by activating inert coupling partners in separate catalytic cycles.
Recent advances in catalytic asymmetric reactions of Morita–Baylis–Hillman adducts
Morita–Baylis–Hillman adducts have become an efficient synthon for the construction of C–C or C–heteroatom bonds, and have been widely used in the asymmetric synthesis of various new optically pure compounds.
Progress in the catalytic enantioselective construction of difluoroalkylated stereogenic centers
This review focuses on the progress in catalytic asymmetric difluoroalkylation to construction of difluoroalkylated stereogenic centers. Synthetic methods, active intermediates involved and asymmetric strategies applied were summarized.
Asymmetric synthesis of chiral sp3-geminated borylstannyl, borylsilyl, and diboryl compounds
Chiral sp3-geminated bimetallic reagents based on B, Si, and Sn have drawn much attention due to their unique structure and reaction mode. This review summarizes the synthesis of nonracemic gem-borylstannyl, gem-borylsilyl, and gem-diboryl compounds.
Achievements in the Photocatalytic Povarov–Type Reactions: a Key Step in Green Diversifying the Chemical Quinoline Space
Review Article
Mechanophoric hydrogels: when mechanical stress produces useful responses
Mechanophoric hydrogels undergo visible color changes or alterations in optical properties in response to mechanical stimuli.
Recent advances in the synthesis of nitrogen heterocycles via Rh(III)-catalyzed chelation-assisted C–H activation/annulation with diazo compounds
The advancements in the synthesis of nitrogen-containing heterocycles via Rh(III)-catalyzed chelation-assisted tandem C–H activation/carbene insertion/annulation with diazo compounds as carbene precursors have been summarized.
Recent advances in enantioselective construction of C–N bonds involving radical intermediates
This review offers a comprehensive overview of recent advancements in the asymmetric construction of C–N bonds involving radical intermediates.
Review Article
Remodelling molecular frameworks via atom-level surgery: recent advances in skeletal editing of (hetero)cycles
Skeletal editing enables atom-level modifications to molecular skeletons. This review highlights advances in single-atom insertions, deletions, and transmutations in (hetero)cyclic systems, offering a comprehensive view on cutting-edge strategies.
Photochemical generation of heteroatom (N, Si, B) or carbon radicals leveraging preinstalled carboxylic acids
This review provides an overview of recent advancements in generating N, Si, B, and C radicals through the decarboxylation of preinstalled carboxyl substrates under visible light catalysis.
Advances in the synthesis of indolizines and their π-expanded analogues: update 2016–2024
Developments in the synthesis of indolizines during the last decade are reviewed, with special emphasis given to strategies relying on pyrrole derivatives and on π-expanded systems.
UV/visible light-promoted external photocatalyst-free transformations: A Decade's Journey of N-heterocycles and their functionalisation
We have provided a comprehensive analysis of the construction of N-containing heterocyclic compounds and their functionalization without the use of external photocatalysts, under UV/visible-light exposure in different conditions.
Review Article
AI molecular catalysis: where are we now?
Artificial intelligence (AI) is transforming molecular catalysis by addressing long-standing challenges in retrosynthetic design, catalyst design, reaction development, and autonomous experimentation.
Polyfluorinated reagents for peptide stapling
Fluorinated reagents have emerged as a valuable tool in peptide chemistry. This review summarizes recent advances in polyfluorinated reagents for peptide stapling, exploring their design principles, reaction mechanisms, and biological applications.
Recent advances in hydrofunctionalisation of cyclopropenes via carbon–heteroatom bond formation
This review highlights recent advances in the hydrofunctionalisation of cyclopropenes through the formation of carbon–heteroatom bonds for the synthesis of polysubstituted cyclopropanes.
Recent advances on electrocyclic reactions in complex natural product synthesis: an update
The recent advances on the application of electrocyclic reactions in the total synthesis of notable natural products are summarized.
Recent progress in electrochemical rearrangement reactions
Electrochemical-mediated rearrangement has emerged as one of the most important research fields in organic chemistry. This review systematically summarizes the diverse transformations and applications of electrochemistry in rearrangement reactions.
Nitrogen-containing polycyclic aromatic hydrocarbons (PAHs) with bowl-shaped structures: synthesis, architecture, and applications
This highlight discusses the synthesis strategies and topological features of nitrogen-containing bowl-shaped polycyclic aromatic hydrocarbons.
Organic reactions catalyzed by the Brønsted acid B(C6F5)3·H2O
This article reviews the organic reactions catalyzed by the Brønsted acid B(C6F5)3·H2O and their mechanisms, along with an outlook on its future catalytic prospects.
Review Article
Advances in synthetic strategies for two-dimensional conjugated polymers
This review covers synthetic approaches towards crystalline 2D conjugated polymers linked by imines, pyrazines, vinylenes, C–C, or imidazoles. It explores the interplay between structures and properties, highlighting their prospects in electronics.
Total synthesis of cyclopropane-containing natural products: recent progress (2016–2024)
This review outlines recent progress in the total synthesis of cyclopropane-containing natural products, with a particular focus on the application of novel synthetic methodologies and tactics for assembling naturally occurring three-membered rings.
About this collection
Critical reviews, highlights and chemistry frontiers articles published in Organic Chemistry Frontiers during 2025 are collated as below for the benefit of readers.