Themed collection Most popular 2024 analytical chemistry articles

An overview of structural responses of helicenes with increasing dimensions and complexity to stepwise electron addition reveals charge- and topology-dependent outcomes ranging from reversible to irreversible core transformations and site-specific reactivity.

This Perspective provides an overview of the recent progress in the field of bioresponsive MRI probes, highlighting the richness in research approaches and achievements in the visualisation and assessment of important biological markers.

This perspective outlines three potential routes for nanopore-based glycan sequencing, highlighting their potential applications and offering insights to meet associated challenges. It also introduces the concept of nanopore-based glycan sequencer.

Recent synthetic approaches for AIEzymes and their diverse applications in tumor imaging and therapy, anti-biofilm and antibacterial, food safety analysis, and environmental pollutant monitoring.

In this review, we summarized the latest progress (2020–2023) in small-molecule fluorescent probes for monitoring superoxide anion (O₂˙⁻), nitric oxide (NO), and peroxynitrite anion (ONOO⁻) in biological systems.

This review covers the recent advances in flexible piezoelectric materials, which show great potential for strain sensors in wearable electronics and artificial intelligence, focusing on microstructure engineering and fabrication techniques.

Fluorescent probes for detecting complex environments in vivo play an important role in self-assembly in vitro.

A lytic polysaccharide monooxygenase's ligands and their electronic influences are revealed by advanced electron paramagnetic resonance spectroscopies.

An economical method for highly enantioselective and diastereoselective synthesis of 1,2-syn-tert,sec-diols via Cu-BINAP-catalysed reductive coupling of alkoxyallenes with ketones.

Reactive oxygen species (ROS) play critical roles in normal physiological processes including cellular signaling and immune responses.

Super-resolution nanoscopic visualization of lysosomal speed and their in vivo embryogenic evolution using a highly bright and photostable NIR emissive zinc metal complex.

A zwitterionic chemiluminescence strategy makes a breakthrough in highly selective sensing of ¹O₂ towards FDA-approved phototherapy through suppressing inherent photo-induced side reactions.

A water-soluble, cell-permeable, turn-on Mn²⁺ sensor visualizes Mn²⁺ dynamics live and provides an estimate for endogenous labile Mn²⁺ in a living mammalian cell.

We introduce a new non-enzymatic method that detects HCV-RNA and forms gold nanoparticle assemblies for quantification through colorimetric and spectroscopic means.

A collection of single Au nanoparticles (NPs) and NP clusters were individually tested for the borohydride oxidation reaction. Significant variation in the activity could not be attributed to NP size, and ∼67% of NP locations displayed no activity.

A mitochondria-localizing iridium(III) photosensitizer produces singlet oxygen and superoxide anion radicals upon two-photon irradiation, disrupting the mitochondrial respiratory chain and inducing ferritinophagy and immunogenic cell death.

We propose a pyrazine-based planar electronic acceptor with strong electron affinity which can be further utilized to design NIR-II fluorescence dyes with combined imaging and therapeutic applications.

A NIR fluorescent probe for monitoring senescence was developed with SA-β-gal and HClO as targets under high lysosomal pH conditions. The precise tracking of cellular/in vivo senescence was achieved with a ratiometric sensing pattern.

Introducing 4-amino-3-thiophenol BODIPY “turn on” probe tunable to NIR wavelengths for monitoring aldehydes in tissues and living organoids by forming dihydrobenzothiazole products with aldehydes, exhibiting a remarkable fluorescence increase.

Biocompatible fluorescent BODIPY probes with excellent quantum yields, demonstrating a high mitochondrial membrane potential (MMP)-sensitive localisation in the mitochondria. PEGylation improved biocompatibility and lowers cytotoxicity.

This study presents a new type of boron carrier for boron neutron capture therapy that integrates imaging, a lung cancer targeting drug and carborane, and showcases an impressive therapeutic efficacy against lung tumors both in vitro and in vivo.

A ratiometric, near-infrared fluorescent molecular probe reports nitroreductase activity and enables three-dimensional optical sectioning of intact tumor spheroids with visualization of individual hypoxic cells.

Multi-wavelength LED excited NIR-II imaging strategy based on a blue-shifted dye—TPA-TQT.

We report for the first time the phenomenon of continuously color-tunable ECL from individual Au NCs confined in a porous hydrogel matrix. The color-tunable ECL property arises from the dynamic surface reconstruction of Au NCs and co-reactants.

Photo-induced electrochemiluminescence imaging of single cells is reported using an infrared light stimulus.

We have designed a deoxyribonucleic acid-gold nanocluster (DNA-AuNC) nanomachine for long-term imaging of mRNA and protease, harnessing the toehold-mediated stand displacement (TMSD) reaction-driven aggregation-induced enhanced emission of AuNCs.