Chemistry of detrifluoroacetylatively in situ generated fluoro-enolates

Haibo Mei; Jiang Liu; Santos Fustero; Raquel Román; Renzo Ruzziconi; Vadim A. Soloshonok; Jianlin Han

doi:10.1039/C8OB02843E

Chemistry of detrifluoroacetylatively in situ generated fluoro-enolates

Haibo Mei,

^a Jiang Liu,^a Santos Fustero,

*^bc Raquel Román,

^bc Renzo Ruzziconi,

*^d Vadim A. Soloshonok

*^ef and Jianlin Han

*^a

Author affiliations

* Corresponding authors

^a College of Chemical Engineering, Nanjing Forestry University, Nanjing, 210037 Jiangsu, China
E-mail: hanjl@njfu.edu.cn

^b Departamento de Química Orgánica, Universidad de Valencia, 46100 Burjassot, Valencia, Spain
E-mail: santos.fustero@uv.es

^c Laboratorio de Moléculas Orgánicas, Centro de Investigación Príncipe Felipe, 46012 Valencia, Spain

^d Department of Chemistry, Biology and Biotechnologies, Via Elce di Sotto 8, 06123 Perugia, Italy
E-mail: renzo.ruzziconi@unipg.it

^e Department of Organic Chemistry I, Faculty of Chemistry, University of the Basque Country UPV/EHU, Paseo Manuel Lardizábal 3, 20018 San Sebastián, Spain
E-mail: vadym.soloshonok@ehu.es

^f IKERBASQUE, Basque Foundation for Science, María Díaz de Haro 3, Plaza Bizkaia, 48013 Bilbao, Spain

Abstract

This review article comprehensively profiles all literature reports (2015–2018) related to the detrifluoroacetylative in situ generation of fluorine-containing enolates and their reactions with electrophilic reagents. The innovative facets of this unconventional methodology and its synthetic generality for the preparation of fluorine-containing compounds of high medicinal value are highlighted.

This article is part of the themed collections: Synthetic methodology in OBC and Fluorine Chemistry

Article information

https://doi.org/10.1039/C8OB02843E

Article type

Review Article

Submitted

15 11 2018

Accepted

13 12 2018

First published

13 12 2018

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Org. Biomol. Chem., 2019,17, 762-775

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Chemistry of detrifluoroacetylatively in situ generated fluoro-enolates

H. Mei, J. Liu, S. Fustero, R. Román, R. Ruzziconi, V. A. Soloshonok and J. Han, Org. Biomol. Chem., 2019, 17, 762 DOI: 10.1039/C8OB02843E

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Organic & Biomolecular Chemistry

Chemistry of detrifluoroacetylatively in situ generated fluoro-enolates

Abstract

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Chemistry of detrifluoroacetylatively in situ generated fluoro-enolates

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