Themed collection #MyFirstChemSci 2025

This review highlights the mechanisms underlying the unique fluorogenic properties of tetrazine-functionalized labels and proposes new strategies to enhance fluorogenicity in the near-infrared region.

Spray-drying, a rapid, continuous, and widely used industrial process that atomizes microdroplets and dries them in a hot gas stream, is employed to conduct chemical reactions for the synthesis of small organic molecules such as paracetamol.

In this manuscript, the piezochromism and thermochromism of phase-stable 2D hybrid perovskites containing a rigid organic bilayer are explored. Dual-band emission from single crystals is linked to emission from both the surface and the bulk.

Group 13 aminoxy complexes, (L)E(TEMPO)₃ (TEMPO = 2,2,6,6-tetramethylpiperidine 1-oxyl; L = THF (tetrahydrofuran) or Py (pyridine); E = Al, Ga, In), display ambiphilic reactivity with H₂ and function as synthons for the preparation of materials.

A new class of mercapto-NSAIDs that generate persulfide, H₂S, and the NSAID is reported.

Thiosemicarbazones exhibit versatile photochromic and supramolecular properties, making them excellent photoswitches for designing systems that respond to external stimuli.

Ligand-directed chemistry (LDchem) sialyltransferases (ST) probes with an O-nitrobenzoxadiazole warhead enable selective fluorescent labelling of a wide range of recombinant STs and native lipooligosaccharide ST (Lst) in Neisseria gonorrhoeae.

Developing a self-sensitized catalyst from earth-abundant elements capable of efficient light harvesting and electron transfer is crucial for enhancing the efficacy of CO₂ reduction, environmental cleanup, and improving clean energy prospects.

We computationally investigated the fragmentation pathways of saturated molecules detected in the interstellar medium, demonstrating how high-energy processes drive their transformation into unsaturated species with extended π-bond networks.

Characterization of 2PA of DNA-stabilized silver nanoclusters (Ag_N-DNAs) with far-red to NIR emission identify them as water-soluble two-photon absorbers.

We have demonstrated the synthesis of regio- and diastereoselective cyclobutylated phenothiazines via [2 + 2] visible-light-irradiated cycloaddition and wavelength-gated cycloreversion inside the live cells for cell imaging and drug delivery.