A carbamazepine-indomethacin (1 : 1) cocrystal produced by milling

Mridul Majumder; Graham Buckton; Clare Rawlinson-Malone; Adrian C. Williams; Mark J. Spillman; Norman Shankland; Kenneth Shankland

doi:10.1039/C1CE05650F

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A carbamazepine-indomethacin (1 : 1) cocrystal produced by milling†

Mridul Majumder,^ab Graham Buckton,^ac Clare Rawlinson-Malone,^d Adrian C. Williams,^b Mark J. Spillman,^b Norman Shankland^e and Kenneth Shankland*^b

Author affiliations

* Corresponding authors

^a Pharmaterials Ltd., Unit B, 5 Boulton Road, Reading, UK
E-mail: mridul.majumder@pharmaterials.co.uk
Fax: +44 (0) 1189 310679
Tel: +44 (0) 1189 209900

^b School of Pharmacy, University of Reading, Whiteknights, Reading, UK

^c School of Pharmacy, University of London, 29–39 Brunswick Square, London, UK

^d Bristol-Myers Squibb Pharmaceuticals Limited, Reeds Lane, Moreton, UK

^e Crystallografx Ltd, 2 Stewart St., Milngavie, Glasgow, UK

Abstract

An X-ray amorphous mixture of carbamazepine and indomethacin transforms upon annealing to produce a novel 1 : 1 cocrystal, whose structure has been determined from laboratory powder X-ray diffraction (PXRD) data.

This article is part of the themed collection: Editor’s Collection: Mechanochemistry

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Article information

DOI: https://doi.org/10.1039/C1CE05650F
Article type: Communication
Submitted: 01 Jūn. 2011
Accepted: 04 Aug. 2011
First published: 14 Sept. 2011

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CrystEngComm, 2011,13, 6327-6328

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A carbamazepine-indomethacin (1 : 1) cocrystal produced by milling

M. Majumder, G. Buckton, C. Rawlinson-Malone, A. C. Williams, M. J. Spillman, N. Shankland and K. Shankland, CrystEngComm, 2011, 13, 6327 DOI: 10.1039/C1CE05650F

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