Issue 4, 2019
From the journal:

Organic & Biomolecular Chemistry

Use of plant hormones to activate silent polyketide biosynthetic pathways in Arthrinium sacchari, a fungus isolated from a spider†

Yohei Morishita,a   Yusuke Okazaki,a   Yi Yi Luo,a   Jun Nunoki,b   Tohru Taniguchi, ORCID logo c   Yoshiteru Oshimab  and  Teigo Asai ORCID logo *a  

* Corresponding authors

a Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo, 3-8-1 komaba, meguro-ku, Tokyo 153-8902, Japan
E-mail: tasai@bio.c.u-tokyo.ac.jp

b Graduate School of Pharmaceutical Sciences, Tohoku University, Aoba-yama, Aoba-ku, Sendai 980-8578, Japan

c Faculty of Advanced Life Science, Frontier Research Center for Post-Genome Science and Technology, Hokkaido University, Kita 21 Nishi 11, Sapporo 001-0021, Japan

Abstract

Plant hormones were evaluated for their ability to activate fungal secondary metabolite production. Three synthetic cytokinins, kinetin, 6-benzylaminopurine, and forchlorfenuron, showed remarkable enhancement of the production of aromatic polyketides derived from emodin in a fungus, Arthrinium sacchari, and allowed us to isolate a new polyketide. Furthermore, we firstly demonstrated the potential of plant hormones to activate a wide range of fungal secondary metabolite production processes.

Graphical abstract: Use of plant hormones to activate silent polyketide biosynthetic pathways in Arthrinium sacchari, a fungus isolated from a spider

  • This article is part of the themed collection: Biosynthesis
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Article information

DOI
https://doi.org/10.1039/C8OB02837K
Article type
Communication
Submitted
14 Nov. 2018
Accepted
19 Dec. 2018
First published
20 Dec. 2018

Org. Biomol. Chem., 2019,17, 780-784

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Use of plant hormones to activate silent polyketide biosynthetic pathways in Arthrinium sacchari, a fungus isolated from a spider

Y. Morishita, Y. Okazaki, Y. Y. Luo, J. Nunoki, T. Taniguchi, Y. Oshima and T. Asai, Org. Biomol. Chem., 2019, 17, 780 DOI: 10.1039/C8OB02837K

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